A Palladium on Carbon Catalyzed One-Pot Synthesis of Substituted Benzimidazoles

Soumen Joardar; Anjan Bhattacharyya; Saktipada Das

doi:10.1055/s-0034-1378454

Synthesis, Table of Contents

Synthesis 2014; 46(22): 3121-3132
DOI: 10.1055/s-0034-1378454

paper

A Palladium on Carbon Catalyzed One-Pot Synthesis of Substituted Benzimidazoles

Soumen Joardar*

^aChembiotek, TCG Lifesciences Ltd., Kolkata-700 091, West Bengal, India

^bDepartment of Chemistry, University of Kalyani, Kalyani-741 235, West Bengal, India

,

Anjan Bhattacharyya

^cDepartment of Agricultural Chemicals, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur-741 252, Nadia, West Bengal, India Email: joardarsoumen@gmail.com Fax: +91(33)25828282

,

Saktipada Das*

^bDepartment of Chemistry, University of Kalyani, Kalyani-741 235, West Bengal, India

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Abstract

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Abstract

A new and efficient palladium on carbon catalyzed one-pot intramolecular nitro reduction/cyclization reaction has been developed for the preparation of a series of substituted benzimidazoles, including some novel ring-fused [1,2-a]-tricyclic, [1,2-a]-tetracyclic, and chiral benzimidazoles. The main advantages of this method are the mild and simple reaction conditions, the easy isolation of the products, and the excellent yields. The reaction has the potential to be used as a general procedure for the preparation of 7-aminobenzimidazoles in good yields. A plausible mechanism for the reaction is proposed.

Key words

heterocycles - reductions - cyclizations - catalysis - palladium - one-pot reactions

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References

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